Comparing Common ED Medications: Efficacy and Duration

Other > medicine for erectile dysfunction


Many providers that stock generic sildenafil for ED prefer these 20mg tablets because they allow for more dose flexibility from a single stockpile of pills. A doctor can prescribe 20mg, 40mg, 60mg, or 100mg, and the patient simply takes the corresponding number of 20mg pills. Both branded and generic Viagra come in 25mg tablets, 50mg tablets, and 100mg tablets. If the most common dose is 50mg, then those 100mg doses are going to sit on the shelf, gradually approaching their expiration date and causing providers to lose money. Like tadalafil, sildenafil doses can vary to greater degrees, especially as delivery mechanisms change. For example, BlueChew’s chewable tablets come in 30mg and 45mg doses, neither of which exist in the typical dose ranges for pills. Here’s a quick visual reference detailing which versions of sildenafil our top choices offer: Our recommendation here, for most men, is generic sildenafil. Sildenafil is far more economical and allows for better dose tailoring.

Cialis (tadalafil (cialis))

That’s because you could request daily tadalafil tablets on a yearly billing cycle, which brings the cost per dose to nearly $1.00. You could then temporarily cancel your Hims subscription until you make your way through that stock of 360 doses and reinstate it whenever you need more. Canceling and restarting through Hims carries no financial penalty. That said, BlueChew offers a free month of as-needed tadalafil as a way to test their service; all you pay is a small shipping fee. That means you can see if these medications work for your ED for a $5 shipping charge.

Be physically active

So, if you want to maximize your savings and you don’t mind the hassle of dealing with two or three companies, your path may look something like this: Try BlueChew’s 6mg tadalafil chews (as needed) to see if the medication is effective for you. If it is, consider switching to Hims (either chews or pills) to get the best price per dose on your medication. If you find you need a stronger dose, you can head to Rocket Rx, which has the best prices for 10mg and 20mg doses. The window of effectiveness requires a bit of planning Loses efficacy when you take it with meals Mild side effects, such headaches, are more common than with other treatments like Stendra Most people can’t predict with complete certainty whether or not they’ll have sex on any given day. Even if you’re accustomed to daily intercourse, your partner could get sick, you could strike out at the club, or your in-laws could pay you a surprise visit. Rocket Rx has the best prices for sildenafil on the market, and it offers these prices without a major commitment. While low prices from Hims and Strut rely on lower doses or 5-12-month billing cenforce 200 uk cycles, Rocket gets you low prices from orders containing up to 64 tablets.

Product Dosage Quantity + Bonus Price
Viagra Generic100mg20 Pills45.58€ 43.41€
Viagra Generic50mg10 Pills26.87€ 25.59€
Kamagra100mg84 + 6 Pills264.44€ 251.85€
Levitra Original20mg48 + 4 Pills235.14€ 223.94€
Kamagra Gold100 mg180 + 6 Pills436.79€ 415.99€
Viagra Generic150mg360 + 10 Pills423.48€ 403.31€
Apcalis SX Oral Jelly20mg30 + 5 Sachets141.84€ 135.09€
Levitra Original20mg14 + 2 Pills102.27€ 97.40€
Kamagra Oral Jelly100 mg10 Sachets54.55€ 51.95€
Kamagra Gold100 mg120 + 6 Pills330.74€ 314.99€

That means you stand to spend a lot less up front to find out if the medication and dose are a fit.

General Considerations

Some men familiar with Viagra, having used it before successfully, want to stick with what works. They trust it, and the brain 10mg vardenafil online is the largest and most important sex organ after all; psychology can be a potent tool in combating ED. But a complete understanding of your options requires a little knowledge about the differences between Viagra, generic Viagra, and generic sildenafil. This is the original “little blue pill,” and it’s the most expensive option. Made by Pfizer, Viagra is available in 25mg, 50mg, and 100mg tablets from most providers.

Frequently Asked Questions

We consider Roman the best choice for branded Viagra thanks to their low per-dose pricing compared to Hims ($90 vs. $138). This is a generic form of Viagra either made by Pfizer or by an authorized company with which Pfizer has shared their exact formula. It’s identical to branded Viagra in every way except that it won’t say “Viagra” on the prescription label. This is one of the least expensive options, though it’s often pricier than generic sildenafil. For men new to ED medication who want to test the waters while spending as little as possible, BlueChew may be a good place to start, if only because the medication is super convenient to take and because the company offers a free trial.

So you can try it out with very little financial risk.

Medication Prescription Needed Typical Dose Range Storage Conditions Special Precautions
Viagra Yes 25-100 mg Room temperature Avoid nitrate use
Cialis Yes 5-20 mg Keep dry, cool Long-lasting effect
Levitra Yes 5-20 mg Protect from light Avoid high-fat meals
Stendra Yes 100-200 mg Store in a dry place Take on an empty stomach

Hims also offers sildenafil in a chew, but only combined with another medication and only at a relatively high combination of doses (which we’ll discuss later in our combination therapy section). However, there are definitely situations in which you might want to opt for Hims’ sildenafil: Hims sildenafil is available in a wider number of doses, making it our top choice for men who find they need to fine-tune or maximize their dosage of sildenafil for the best effect or to reduce side effects. Hims telemedical support is fantastic for men who are dealing with ED alongside efforts to treat premature ejaculation. If you’re one of the many men who already use Hims for hair loss treatment or another service, then it could be convenient to use the same provider for ED treatment as well. Hims offers classic, brand-name Viagra or an authorized generic for men who want it. Hims is also the only company we recommend that sells an authorized generic Viagra.

Seek care right away

These are the doses you’ll see from Hims for its tadalafil tablets. Chewable tablets and lozenges often have different doses. 8.5mg and 11.2mg doses from Hims We’ll get a little more into complex offerings in the “Combination therapies” section later. Ultimately, you’ll decide with the prescribing doctor which dose and schedule are best for your lifestyle. Here’s a quick visual reference to let you know what kinds of branded and generic tadalafil our top choices carry: The tadalafil landscape has gotten a little more complicated in recent years.

Heart Disease/High Blood Pressure

While BlueChew was steadily our top choice for tadalafil for years, Hims has caught up and surpassed it slightly, beating BlueChew to a chewable daily tadalafil offering that could undercut BlueChew’s tadalafil pricing if you only needed a low dose. That said, Hims’ low prices on tadalafil only apply to daily versions of those lower 2.5mg and 5mg doses. Both BlueChew and Hims lag behind Rocket Rx’s pricing for as-needed tadalafil at 10mg and 20mg doses, however. So, the provider that’s best for you will have a lot to do with the dose you need and whether you want to take tadalafil daily or as needed. Here’s how those prices compare, with lower prices often coming from extended billing cycles (quarterly, biannually, etc.): If you’re new to ED meds and want to try as-needed tadalafil at a dosage no stronger than 5mg, then tadalafil from Hims could conceivably be your most economical option. Interestingly, Roman lists their options as “Branded Viagra” and “Generic Viagra.” That second option is actually generic sildenafil — it is not an authorized generic made by Pfizer. Roman lists their sildenafil this way out of the belief that it makes it easier for potential patients to understand that the two drugs are practically identical.

Drug Type Mechanism of Action Target Enzyme/Pathway Typical Use Cases
PDE5 Inhibitors Inhibit phosphodiesterase type 5 enzyme PDE5 enzyme Relaxation of penile arteries
Testosterone Replacement Increase testosterone levels Hormonal pathway Hormonal deficiency cases
Vasodilators Directly relax smooth muscle Nitric oxide pathway Severe cases of ED
Melanocortin Agonists Stimulate melanocortin receptors Central nervous system Experimental, limited availability

Visit our Roman review to learn more.

Starts working in as little as 30 minutes Doesn’t cause a particular — but rare — side effect of sildenafil Available in chewable form from BlueChew and Hims While it isn’t the most widely available option from telemedicine providers, vardenafil is an important option for the few men who might not have success taking sildenafil but still want an effective medicine they can take on demand 30-60 minutes before sex. Studies show that vardenafil behaves the same way in the body as sildenafil, with one known exception. A rare side effect of sildenafil is an alteration in color perception due to the drug’s inhibition of PDE6 in addition to PDE5.13 Vardenafil is somewhat more selective in this regard, having no known effect on PDE6 and, therefore, no known effect on color perception.

Information & Authors

For that reason, some men prefer not to take a daily tablet of Cialis or tadalafil when the prospect of sex is not guaranteed. This is even truer for men who’ve experienced some mild side effects from frequent or daily tadalafil use. On the flip side, sildenafil and Viagra (as well as a specific regimen of Cialis and tadalafil) offer you the choice to take them as needed. So, if you want to spend all day in bed playing video games, you don’t have to worry about missing a daily pill. And if you know that sex is on the horizon, you can take these meds accordingly.

Vacuum erectile device

You’ll need to take sildenafil/Viagra 30-60 minutes before sex. Some men report that chewables and lozenges kick in faster than pills, but this is not guaranteed. Viagra’s active ingredient is sildenafil, but you might not know it from looking around at your ED options. Why would Viagra be so much more expensive than sildenafil (the active ingredient in Viagra)? Why does anyone opt for the more expensive Viagra if both have the same ingredient? And while vardenafil is less thoroughly researched than sildenafil, there are still numerous studies looking at thousands of users over nearly two decades, so its safety and efficacy are without question.14 For a while, BlueChew was the only provider among our top picks to offer vardenafil, but Hims has included it in its recent development of chewable mint tablets.

Area of Research Description Promising Developments Challenges
Gene Therapy Targeting genetic causes of ED Experimental treatments Delivery and safety concerns
Stem Cell Therapy Regenerating erectile tissue Early clinical trials Efficacy and long-term effects
NO-Donors and Nitric Oxide Modulators Enhancing natural nitric oxide production New drug candidates Side effects and regulation
Pharmacogenomics Personalized medicine based on genetics Custom drug development Complexity of genetic profiling

Despite not typically being a daily medication, Hims offers a 30-day supply of vardenafil that bears the same low price as its daily tadalafil. As a result, you can get 8.5mg vardenafil chews from Hims for significantly less than you can from BlueChew. Hims’ low price on vardenafil reflects their pricing for a 150-day supply.

What Are the Best Medications for Erectile Dysfunction?

This is a formula therapeutically identical to branded Viagra but with discrepancies in inactive ingredients, color, shape, and delivery mechanism. Doses are theoretically supposed to be the same, but there are caveats. This is often the least expensive option. Sildenafil is also the active ingredient in Revatio, a drug designed to treat pulmonary arterial hypertension. The drugs are identical in almost every way — they’re even both made by Pfizer — but Revatio is made only in 20mg tablets. If you don’t want to stockpile vardenafil like that, the next-lowest price per dose you can get from Hims on smaller quantities of vardenafil is $6, which is more expensive than even the highest price per dose from BlueChew.