Sildenafil oral spray - Aspargo Laboratories

The goal, therefore, is to create a more convenient, rapid-acting ED medication without food interference. The introduction of a new delivery system shows promise in overcoming these challenges.

Fact Box

Adverse events should also be reported to Aspargo Labs by emailing safety@aspargolabs.com or by calling 01480 465755 Reporting forms and information can be found at or search for MHRA Yellow Card in the Google Play or Apple App Store. Adverse events should also be reported to Aspargo Labs by emailing safety@aspargolabs.com or by calling 01480 465755 During a typical ED consultation for erectile dysfunction treatment, the conversation might go like this: Me: “What did you book this consultation for today?”Man (glancing at his feet): “I think I have erectile dysfunction.”Me: “No worries. This is a common issue—did you know that 1 in 3 men over 45 experience erectile dysfunction? Even younger blokes can face these challenges. What treatments or ED medications have you tried so far?”Man: “I tried Viagra, but it didn’t work.”Me: “Did you wait at least an hour after taking it before stimulation?

2. Topical ED gels (like MED3000/Eroxon)

Proper ED medication use is crucial.”Man: “No.”Me: “And did you know that taking sildenafil on an empty stomach makes a big difference? That’s an important detail in effective erectile dysfunction treatment.”Man: “No—I took it after dinner with my partner.” After this exchange, I explain how these medications work, their differences, and the correct way to use them—emphasising that details like timing and meal choices are critical to successful ED treatment. Most of us know about the “magic blue pill” and its siblings. These medications are available in various forms: Capsules, tablets, troches, oral strips, and nasal spray delivery. Timing Is Crucial:The devil is in the details when it comes to ED medications—they only work if taken correctly.

Most Asked Questions

For example, sildenafil works best on an empty stomach because high-fat meals can delay its absorption, and it typically takes about one hour to start working. Similarly, tadalafil lasts longer in the body but also generally requires roughly one hour to reach maximum effect. In contrast, intranasal formulations—such as nasal spray forms of Levitra and oral Avanafil—are designed for a faster onset, usually working within 15 to 30 minutes. This faster absorption could reduce the necessary dosage and side effects while improving overall efficacy. The hope is that faster absorption will lead to quicker results, helping patients avoid more invasive treatments like penile injections or surgeries.

The medication is currently in the testing phase, focusing on its food effects, absorption rate and overall efficacy. Kaplan and his team aim to receive US Food and Drug Administration (FDA) approval in the US by 2025. This innovation is not just about creating new drugs, he said, but also repurposing existing medications with better delivery methods to enhance patient outcomes. The integration of new technology, such as a discrete and convenient delivery device, is also seen as a major advancement in ED treatment. Overall, he emphasized that innovation in medical treatments continues to evolve, providing hope and better health outcomes for patients struggling with ED. The spray is a liquid suspension of sildenafil citrate administered orally via a spray pump. The German Federal Institute for Drugs and Medical Devices has granted regulatory approval to market Sildenafil oral spray (trade name, Hezkue) for erectile dysfunction (ED) in Germany. The spray was also recently approved for marketability in Ireland and the Netherlands, according to a liquid sildenafil citrate news release from Aspargo Laboratories, the developer of the treatment.1 The German market is the largest in the EU, and the aggregate erectile dysfunction market for Germany, Ireland, and the Netherlands exceeds $175 million. “These product approvals reflect Aspargo’s commitment to quickly expand its global platform to the EU during 2023. The Marketing Authorizations are an important achievement.

Can you use a Sildenafil Suspension and Sildenafil tablets at the same time?

WARNINGSCardiovascular disease, left ventricular outflow obstruction, severe autonomic dysfunction, severe renal impairment (CrCl <30ml/min), mild to moderate hepatic impairment. Abnormal penile anatomy or predisposition to priapism (eg, sickle cell anaemia, multiple myeloma or leukaemia). Advise patients to report immediately any sudden changes in vision (and to discontinue treatment if occur) or erection lasting >4 hrs. Common: dizziness, visual colour distortions, visual disturbance, vision blurred, flushing, nasal congestion, nausea, dyspepsia. ● Hezkue® is the first PDE-5 inhibitor suspension spray for erectile dysfunction that offers flexible dose adjustment based on individual patient needs.2 Hezkue® uses a suspension technology that provides fast absorption starting within 5 minutes.2–4● A prospective open-label, single-centre, two-way crossover study evaluated the pharmacokinetics, safety and tolerability of 100mg of sildenafil oromucosal spray (8 pumps) and 100mg sildenafil (Viagra®) tablets in 52 fasted healthy male volunteers.3 ● Initial absorption of sildenafil oromucosal spray was observed within 5 minutes of administration, while sildenafil tablets showed no absorption at that time.

8.7 Patients with Renal Impairment

The absorption rate (Cmax/time of the maximum plasma concentration [Tmax]) of the oromucosal spray was statistically significantly faster than sildenafil tablets at 5–20 minutes and twice as fast as that of sildenafil tablets 20 minutes after administration (16.00ng/ml/min versus 7.84ng/ml/min, p<0.01). The rate of absorption was not significantly different overall between the oromucosal spray and tablets. In addition, the bioavailability (area under the curve [AUC] ratio) was three times higher for the oromucosal spray than for the tablets 20 minutes after administration (646.92ng/ml/min versus 199.21ng/ml/min, p<0.01).3,4● Sildenafil oromucosal spray delivers the same efficacious doses as sildenafil tablets, with no new safety concerns or oral mucosal safety issues.2,3● In a cross-sectional study, 81 sexually active men with new-onset sexual dysfunction, were treated with sildenafil 50mg orodispersible film for 12 weeks then, after washout, with sildenafil 50mg oral suspension for 12 weeks. At follow-up after each 12-week period, patients completed the International Index of Erectile Function (IIEF), the Patient Global Impression of Improvement (PGI-I) and the Psychological and Interpersonal Relationship Scales-Short Form (PAIRS-SF) questionnaires. Sildenafil oral suspension demonstrated higher satisfaction and spontaneity scores and better overall patient satisfaction when compared with sildenafil orodispersible film (all p<0.01).5● A nationwide Spanish study of 30 urologists and andrologists, aggregating information from the last 6 patients who attended their practice who were treated with Hezkue®, indicated that most patients were highly satisfied with the product due to its formulation, opportunities for flexible dosing, convenience and discreetness.6 Pharmacokinetic parameters of a novel sildenafil oral liquid suspension administered to healthy adult men under fasted conditions.

Why can Silfin Oral Spray lower blood pressure?

Effectiveness and patient satisfaction with the new sildenafil oral suspension formulation compared to sildenafil oro-dispersible film: a real-life study. Study UNICO: perception of urologists and andrologists, in Spain, about the use of sildenafil oral suspension in patients with erectile dysfunction. For more information contact Aspargo UK, 2 Cabot House, Compass Point Business Park, St Ives, United Kingdom, PE27 5JL. Legal information, Aspargo Labs Italia S.r.l., Via Po, 102, 00198 Rome – Italy. Reporting forms and information can be found women sildenafil at or search for MHRA Yellow Card in the Google Play or Apple App Store. They validate Aspargo’s international regulatory strategy and confirm that Aspargo meets the highest standards required to ensure the safe distribution of sildenafil spray,” said Michael Demurjian, Chairman and Chief Executive Officer of Aspargo. Hezkue 12.5mg per actuation, oral suspension was developed by the specialty pharmaceutical group Aspargo Laboratories Inc. in partnership with their commercialization consultant, Syneos Health.

• Sildenafil spray is a topical form used for erectile dysfunction treatment.
• It offers quick absorption due to its spray formulation.
• Typically, sildenafil spray acts faster than oral tablets.
• The spray is applied under the tongue for rapid effect.
• Dosage varies depending on individual health and response.
• It is important to follow prescribed instructions for safety.
• Sildenafil spray may cause side effects like headache or flushing.
• It should not be used with nitrates or certain medications.
• Long-term safety data on sildenafil spray is limited.
• It is prescribed by a healthcare professional.
• Always store sildenafil spray in a cool, dry place.

The 2 groups held focus groups and conducted surveys with physicians, pharmacists, and patients throughout the development process.

Can I use Hezkue spray every day?

Aspargo uses a metered-dose pump so that it can deliver the precise, customized dose per push based on the needs of the patient. According to Aspargo, Sildenafil spray is also discreet, easy to carry, and allows patients to avoid crushing or splitting pills with the traditional tablet medications currently available for ED. Aspargo Laboratories is currently seeking FDA approval to market Sildenafil spray in the United States. Aspargo receives regulatory approval to market sildenafil spray in Germany, Ireland, and the Netherlands.

How long will Hezkue take to work?

Hezkue 12.5mg per actuation, oral suspension was developed by the specialty pharmaceutical group Aspargo Laboratories Inc. in partnership with their commercialization consultant, Syneos Health. The 2 groups held focus groups and conducted surveys with physicians, pharmacists, and patients throughout the development process. Aspargo uses a metered-dose pump so that it can deliver the precise, customized dose per push based on the needs of the patient. According to Aspargo, Sildenafil spray is also discreet, easy to carry, and allows patients to avoid crushing or splitting pills with the traditional tablet medications currently available for ED.

Is delay spray same as impotence spray?

Aspargo Laboratories is currently seeking FDA approval to market Sildenafil spray in the United States. Aspargo receives regulatory approval to market sildenafil spray in Germany, Ireland, and the Netherlands. Conventional treatments for erectile dysfunction (ED) require planning and may cause timing anxiety with delayed onset of action.1 Hezkue®, a sildenafil suspension, is the first phosphodiesterase type 5 (PDE-5) inhibitor suspension spray for ED that offers flexible dose adjustment based on individual patient needs.2 The below is a MIMS summary of the Hezkue® product characteristics. Please refer to the full Summary of Product Characteristics (SPC) before prescribing. INDICATIONAdult men with erectile dysfunction, which is the inability to achieve or maintain a penile erection sufficient for satisfactory sexual performance.

1. Delay sprays (lidocaine/benzocaine)

In order for Hezkue to be effective, sexual stimulation is required. DOSAGEAdult: Recommended dose is 50mg (4 actuations) orally approx 1 hr before sexual activity. This may be decreased to 25mg (2 actuations) or increased to 100mg (8 actuations) as needed; max 100mg sildenafil 100mg blue pill once daily. CONTRAINDICATIONSHypersensitivity to the active substance or excipients. Cardiac conditions where sexual activity is inadvisable, non-arteritic anterior ischaemic optic neuropathy, severe hepatic impairment, hypotension, recent stroke or MI, hereditary degenerative retinal disorders. Conventional treatments for erectile dysfunction (ED) require planning and may cause timing anxiety with delayed onset of action.1 Hezkue®, a sildenafil suspension, is the first phosphodiesterase type 5 (PDE-5) inhibitor suspension spray for ED that offers flexible dose adjustment based on individual patient needs.2 The below is a MIMS summary of the Hezkue® product characteristics. Please refer to the full Summary of Product Characteristics (SPC) before prescribing. INDICATIONAdult men with erectile dysfunction, which is the inability to achieve or maintain a penile erection sufficient for satisfactory sexual performance. In order for Hezkue to be effective, sexual stimulation is required. DOSAGEAdult: Recommended dose is 50mg (4 actuations) orally approx 1 hr before sexual activity. This may be decreased to 25mg (2 actuations) or increased to 100mg (8 actuations) as needed; max 100mg sildenafil 100mg blue pill once daily. CONTRAINDICATIONSHypersensitivity to the active substance or excipients.

• Sildenafil spray utilizes absorption through oral mucosa.
• It provides a discreet alternative for erectile issues.
• Use the spray about 10-20 minutes before intimacy.
• It generally has fewer gastrointestinal side effects.
• The spray must be kept out of reach of children.
• Users should avoid alcohol to prevent adverse reactions.
• Compatibility with other medications should be checked.
• The spray may be part of a comprehensive ED treatment plan.
• Discontinue use and consult a doctor if adverse reactions occur.
• The spray’s effectiveness can improve confidence in men.
• Training on proper application enhances safety and effectiveness.

Cardiac conditions where sexual activity is inadvisable, non-arteritic anterior ischaemic optic neuropathy, severe hepatic impairment, hypotension, recent stroke or MI, hereditary degenerative retinal disorders. WARNINGSCardiovascular disease, left ventricular outflow obstruction, severe autonomic dysfunction, severe renal impairment (CrCl <30ml/min), mild to moderate hepatic impairment. Abnormal penile anatomy or predisposition to priapism (eg, sickle cell anaemia, multiple myeloma or leukaemia).

Benefits and Advantages Over Traditional ED Tablets

The goal, therefore, is to create a more convenient, rapid-acting ED medication without food interference. The introduction of a new delivery system shows promise in overcoming these challenges. This faster absorption could reduce the necessary dosage and side effects while improving overall efficacy. The hope is that faster absorption will lead to quicker results, helping patients avoid more invasive treatments like penile injections or surgeries. The medication is currently in the testing phase, focusing on its food effects, absorption rate and overall efficacy.

Why should Silfin Oral Spray not be used with nitrates?

Kaplan and his team aim to receive US Food and Drug Administration (FDA) approval in the US by 2025. This innovation is not just about creating new drugs, he said, but also repurposing existing medications with better delivery methods to enhance patient outcomes. The integration of new technology, such as a discrete and convenient delivery device, is also seen as a major advancement in ED treatment. Overall, he emphasized that innovation in medical treatments continues to evolve, providing hope and better health outcomes for patients struggling with ED. The spray is a liquid suspension of sildenafil citrate administered orally via a spray pump.

Can I take Silfin Oral Spray as often as I want?

The German Federal Institute for Drugs and Medical Devices has granted regulatory approval to market Sildenafil oral spray (trade name, Hezkue) for erectile dysfunction (ED) in Germany. The spray was also recently approved for marketability in Ireland and the Netherlands, according to a liquid sildenafil citrate news release from Aspargo Laboratories, the developer of the treatment.1 The German market is the largest in the EU, and the aggregate erectile dysfunction market for Germany, Ireland, and the Netherlands exceeds $175 million. “These product approvals reflect Aspargo’s commitment to quickly expand its global platform to the EU during 2023. The Marketing Authorizations are an important achievement. They validate Aspargo’s international regulatory strategy and confirm that Aspargo meets the highest standards required to ensure the safe distribution of sildenafil spray,” said Michael Demurjian, Chairman and Chief Executive Officer of Aspargo. Advise patients to report immediately any sudden changes in vision (and to discontinue treatment if occur) or erection lasting >4 hrs. Common: dizziness, visual colour distortions, visual disturbance, vision blurred, flushing, nasal congestion, nausea, dyspepsia. ● Hezkue® is the first PDE-5 inhibitor suspension spray for erectile dysfunction that offers flexible dose adjustment based on individual patient needs.2 Hezkue® uses a suspension technology that provides fast absorption starting within 5 minutes.2–4● A prospective open-label, single-centre, two-way crossover study evaluated the pharmacokinetics, safety and tolerability of 100mg of sildenafil oromucosal spray (8 pumps) and 100mg sildenafil (Viagra®) tablets in 52 fasted healthy male volunteers.3 ● Initial absorption of sildenafil oromucosal spray was observed within 5 minutes of administration, while sildenafil tablets showed no absorption at that time. The absorption rate (Cmax/time of the maximum plasma concentration [Tmax]) of the oromucosal spray was statistically significantly faster than sildenafil tablets at 5–20 minutes and twice as fast as that of sildenafil tablets 20 minutes after administration (16.00ng/ml/min versus 7.84ng/ml/min, p<0.01). The rate of absorption was not significantly different overall between the oromucosal spray and tablets. In addition, the bioavailability (area under the curve [AUC] ratio) was three times higher for the oromucosal spray than for the tablets 20 minutes after administration (646.92ng/ml/min versus 199.21ng/ml/min, p<0.01).3,4● Sildenafil oromucosal spray delivers the same efficacious doses as sildenafil tablets, with no new safety concerns or oral mucosal safety issues.2,3● In a cross-sectional study, 81 sexually active men with new-onset sexual dysfunction, were treated with sildenafil 50mg orodispersible film for 12 weeks then, after washout, with sildenafil 50mg oral suspension for 12 weeks. At follow-up after each 12-week period, patients completed the International Index of Erectile Function (IIEF), the Patient Global Impression of Improvement (PGI-I) and the Psychological and Interpersonal Relationship Scales-Short Form (PAIRS-SF) questionnaires. Sildenafil oral suspension demonstrated higher satisfaction and spontaneity scores and better overall patient satisfaction when compared with sildenafil orodispersible film (all p<0.01).5● A nationwide Spanish study of 30 urologists and andrologists, aggregating information from the last 6 patients who attended their practice who were treated with Hezkue®, indicated that most patients were highly satisfied with the product due to its formulation, opportunities for flexible dosing, convenience and discreetness.6 Pharmacokinetic parameters of a novel sildenafil oral liquid suspension administered to healthy adult men under fasted conditions. Effectiveness and patient satisfaction with the new sildenafil oral suspension formulation compared to sildenafil oro-dispersible film: a real-life study. Study UNICO: perception of urologists and andrologists, in Spain, about the use of sildenafil oral suspension in patients with erectile dysfunction. For more information contact Aspargo UK, 2 Cabot House, Compass Point Business Park, St Ives, United Kingdom, PE27 5JL. Legal information, Aspargo Labs Italia S.r.l., Via Po, 102, 00198 Rome – Italy. Reporting forms and information can be found women sildenafil at or search for MHRA Yellow Card in the Google Play or Apple App Store. Adverse events should also be reported to Aspargo Labs by emailing safety@aspargolabs.com or by calling 01480 465755 Reporting forms and information can be found at or search for MHRA Yellow Card in the Google Play or Apple App Store. Adverse events should also be reported to Aspargo Labs by emailing safety@aspargolabs.com or by calling 01480 465755 During a typical ED consultation for erectile dysfunction treatment, the conversation might go like this: Me: “What did you book this consultation for today?”Man (glancing at his feet): “I think I have erectile dysfunction.”Me: “No worries.

This is a common issue—did you know that 1 in 3 men over 45 experience erectile dysfunction? Even younger blokes can face these challenges. What treatments or ED medications have you tried so far?”Man: “I tried Viagra, but it didn’t work.”Me: “Did you wait at least an hour after taking it before stimulation? Proper ED medication use is crucial.”Man: “No.”Me: “And did you know that taking sildenafil on an empty stomach makes a big difference? That’s an important detail in effective erectile dysfunction treatment.”Man: “No—I took it after dinner with my partner.” After this exchange, I explain how these medications work, their differences, and the correct way to use them—emphasising that details like timing and meal choices are critical to successful ED treatment. Most of us know about the “magic blue pill” and its siblings. These medications are available in various forms: Capsules, tablets, troches, oral strips, and nasal spray delivery. Timing Is Crucial:The devil is in the details when it comes to ED medications—they only work if taken correctly. For example, sildenafil works best on an empty stomach because high-fat meals can delay its absorption, and it typically takes about one hour to start working. Similarly, tadalafil lasts longer in the body but also generally requires roughly one hour to reach maximum effect. In contrast, intranasal formulations—such as nasal spray forms of Levitra and oral Avanafil—are designed for a faster onset, usually working within 15 to 30 minutes.