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)Tj 0 Tc T* ( )Tj 0.0007 Tc -0.0007 Tw T* [(Across all trials, VIAGRA im)8.5 (proved the erections)1 ( of 43% of radical prostatectom)8.5 (y patients )]TJ T* [(com)8.4 (p)0.6 (ared to 15% on placebo. )]TJ 0 Tc 0 Tw T* ( )Tj 0.0007 Tc -0.0007 Tw T* [(Subgroup analyses of responses to a global im)8.5 (provem)8.5 (ent question in patients with psychogenic )]TJ T* (etiology in two fixed-dose studies \(total n=179\) )Tj 0.0008 Tc -0.0008 Tw 19.345 0 Td (and two titration studies \(total n=149\) showed )Tj 0.0005 Tc -0.0005 Tw -19.345 -1.165 Td [(84% of VIAGRA patients reported im)8.3 (provem)8.3 (e)-0.7 (nt in)]TJ 0.0006 Tc -0.0006 Tw 20.61 0 Td [( erections com)8.4 (p)0.6 (ared with 26% of placebo. )]TJ 0.0005 Tc -0.0005 Tw -20.61 -1.165 Td [(The changes from)8.3 ( baseline in scoring on the two end point questions \(frequency of succe\ ssful )]TJ 0.0009 Tc -0.0009 Tw T* [(penetration during sexual activity and m)8.7 (aintenance of erections after penetration\) were highly )]TJ 0.0005 Tc -0.0005 Tw 0 -1.18 TD (statistically significantly in favor of VIAGRA)Tj /TT1 1 Tf 0 Tc 0 Tw 18.435 0 Td (.

)Tj /TT0 1 Tf 0.0005 Tc -0.0005 Tw ( Diary data in two of the studies \(n=178\) showed )Tj -18.435 -1.165 Td [(rates of successful intercourse per attem)8.3 (p)0.5 (t of 70% for VIAGRA and 29% for placebo. )]TJ 0 Tc 0 Tw 0 -1.165 TD ( )Tj 0.0005 Tc -0.0005 Tw T* [(A review of population subgroups dem)8.3 (onstrated)]TJ 0.0007 Tc -0.0007 Tw ( efficacy regardless of baseline severity, )Tj 0.0003 Tc -0.0003 Tw T* (etiology, race and age.

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VIAGRA was effective in )Tj 0.0006 Tc -0.0006 Tw 20.005 0 Td (a broad range of ED patients, including those )Tj -20.005 -1.165 Td (with a history of coronary artery sildenafil citrate tablets 150 mg disease, hype)Tj 0.0011 Tc -0.0011 Tw 18.58 0 Td (rtension, other cardiac disease, peripheral vascular )Tj 0.0008 Tc -0.0008 Tw -18.58 -1.165 Td [(disease, diabetes m)8.6 (ellitus, depression, coronary artery bypass graft \(CABG\), radical )]TJ T* [(prostatectom)8.6 (y, transurethral resection of the prostate \(TURP\) and spinal cord inju\ ry, and in )]TJ 0.001 Tc -0.001 Tw T* (patients taking antidepressants/antipsychotics and antihypertensives/diu\ retics.

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)Tj 0 Tc 0 Tw T* ( )Tj 0.0004 Tc -0.0004 Tw T* (Analysis of the safety database showed no appa)Tj 0.0006 Tc -0.0006 Tw (rent difference in the side effect profile in )Tj 0.0004 Tc -0.0004 Tw T* (patients taking VIAGRA with and without anti)Tj 0.0008 Tc -0.0008 Tw 18.795 0 Td [(hypertensive m)8.6 (edication. This analysis was )]TJ 0.0006 Tc -0.0006 Tw -18.795 -1.165 Td [(perform)8.4 (e)-0.6 (d retrospectively, and was not powered to )-1.2 (detect any pre-specified difference in adverse )]TJ 0.001 Tc 0 Tw T* (reactions.

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Percentage of Patients Reporting )Tj 0.0011 Tc 0.0003 Tw 2.568 -1.159 Td [(an Im)8.4 (provem)8.4 (e)2.3 (nt in Erections. )]TJ 0 Tc 0 sildenafil 200 mg Tw 12 0 0 12 59.8642 405.7628 Tm ( )Tj 0.0006 Tc -0.0006 Tw 0.3 -1.165 Td (The patients in studies had varying degrees of ED. One-third to one-half\ of the subjects in these )Tj 0.0009 Tc -0.0009 Tw 0 -1.165 TD [(studies reported successful intercourse at leas)-2.2 (t once during a 4-week, treatm)8.7 (ent-free run-in )]TJ 0.0007 Tc 0 Tw T* (period. )Tj 0 Tc -0.3 -1.165 Td ( )Tj 0.0007 Tc -0.0007 Tw 0.3 -1.165 Td [(In m)8.5 (any of)3.7 ( the studies, of)3.7 ( both f)3.7 (i)-1.5 (xed dose and titration designs, daily diaries were kept by )]TJ 0.0008 Tc -0.0008 Tw T* (patients. In these studies, involving about 1600 patie)Tj 0.0006 Tc -0.0006 Tw 21.065 0 Td (nts, analyses of patient diaries showed no )Tj 0.0003 Tc -0.0003 Tw -21.065 -1.165 Td [(effect of VIAGRA on rates of attem)8.1 (pted interc)]TJ 0.0008 Tc -0.0008 Tw 18.69 0 Td (ourse \(about 2 per week\), but there was clear )Tj 0.0009 Tc -0.0009 Tw -18.69 -1.165 Td [(treatm)8.7 (ent-related im)8.7 (provem)8.7 (ent in sexual function: per patient weekly success rates averaged 1.3 )]TJ 0 Tc 0 Tw T* [(on 50-100 m)7.8 (g of VIAGRA vs 0.4 on placebo; si)]TJ 0.001 Tc -0.001 Tw 19.27 0 Td [(m)8.8 (ilarly, group m)8.8 (ean success rates \(total )]TJ 0.0006 Tc -0.0006 Tw -19.27 -1.165 Td [(successes divided by total attem)8.4 (p)0.6 (ts\) were about 66% on VIAGRA vs about 20% on placebo.

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)]TJ 0 Tc 0 Tw T* ( )Tj 0.0005 Tc -0.0005 Tw T* [(During 3 to 6 m)8.3 (onths of double-blind treatm)8.3 (e)-0.7 (nt or)]TJ 0.0008 Tc -0.0008 Tw 20.12 0 Td [( longer-term)8.6 ( \(1 year\), open-label studies, few )]TJ -20.12 -1.165 Td [(patients withdrew from)8.6 ( active treatm)8.6 (ent for any )]TJ 0.0005 Tc -0.0005 Tw 19.37 0 Td (reason, including lack of effectiveness. At the )Tj 0.0007 Tc -0.0007 Tw -19.37 -1.165 Td [(end of the long-term)8.5 ( study, 88% of patients re)2.2 (ported that VIAGRA im)8.4 (proved their erections. )]TJ 0 Tc 0 Tw T* ( )Tj 0.0007 Tc -0.0007 Tw T* (Men with untreated ED had relatively low baseline scores for all aspects\ of sexual function )Tj T* [(m)8.4 (easured \(again using a 5-point scale\) in the IIEF.

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)Tj 0 Tc T* ( )Tj T* ( )Tj /TT1 1 Tf -0.0013 Tc 0.0013 Tw 0 -1.18 TD [( )-13095 (INDICATION AND USAGE )]TJ /TT0 1 Tf 0.0005 Tc -0.0005 Tw 0 -1.155 TD [(VIAGRA is indicated for the treatm)8.3 (e)-0.7 (nt of erectile dysfunction. )]TJ 0 Tc 0 Tw 0 -1.165 TD ( )Tj T* ( )Tj ET /Artifact <>BDC Q q 1 0 0 1 120.6970062 785.2004395 cm /GS1 gs /Fm0 Do Q EMC /Artifact <>BDC q 1 0 0 1 612 773.2004395 cm /GS1 gs /Fm1 Do Q EMC endstream endobj 382 0 obj <>>>/Resources 385 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 65.791 -7.9 Td (This ) Tj 22.92 0 Td (label ) Tj 26.055 0 Td (may ) Tj 22.71 0 Td (not ) Tj 18.12 0 Td (be ) Tj 14.692 0 Td (the ) Tj 18.023 0 Td (latest ) Tj 29.595 0 Td (approved ) Tj 48.974 0 Td (by ) Tj 14.17 0 Td (FDA.

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) Tj -281.05 -12 Td (For ) Tj 18.96 0 Td (current ) Tj 38.765 0 Td (labeling ) Tj 41.055 0 Td (information, ) Tj 61.25 0 Td (please ) Tj 34.707 0 Td (visit ) Tj 22.299 0 Td ( Tj ET endstream endobj 383 0 obj <>>>/Resources 387 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 0 -7.9 Td ( ) Tj ET endstream endobj 387 0 obj <> endobj 388 0 obj <> endobj 386 0 obj <>stream /This label may not be the latest approved by FDA. For current labeling information, please visit endstream endobj 385 0 obj <> endobj 389 0 obj <> endobj 384 0 obj <>stream /This label may not be the latest approved by FDA.

Property Description Typical Dosage Appearance Packaging Type
Name Sildenafil White 50 mg, 100 mg White, Round Pills Blister Pack
Chemical Formula C22H30N6O4S N/A N/A N/A
Manufacturer Example Pharma Co. N/A N/A N/A
Storage Conditions Store in a cool, dry place N/A N/A N/A

For current labeling information, please visit endstream endobj 381 0 obj <> endobj 376 0 obj <>stream q 1 0 0 1 -8.535767 -1.877228 cm 0 0 612 792 re W n 1 0 0 1 8.535767 1.877228 cm BT /GS0 gs /TT0 1 Tf 12 0 0 12 63.4642 47.6228 Tm ( )Tj 19.25 -0.005 Td (8)Tj 0.0009 Tc -0.0009 Tw -19.25 54.94 Td [(on placebo. In the titration studies \(n=644\) \(with m)8.7 (o)0.9 (st patients eventually receiving 100 m)8.7 (g)0.9 (\), )]TJ 0.0011 Tc -0.0011 Tw sildenafil film tablet 0 -1.165 TD [(results were sim)8.9 (ilar. )]TJ 0 Tc 0 Tw -0.3 -1.165 Td ( )Tj 0.3 -17.655 Td ( )Tj ET q 1 0 0 1 -8.535767 -1.877228 cm 1 g 205.8 524.58 22.86 33.24 re f Q q 1 0 0 1 -8.535767 -1.877228 cm 205.26 524.58 24 33.78 re W n 0.961 w 1 j 1 J 205.8 557.82 22.86 -33.24 re S Q q 1 0 0 1 -8.535767 -1.877228 cm 1 g 262.5 524.58 22.86 87.12 re f Q q 1 0 0 1 -8.535767 -1.877228 cm 261.96 524.58 24 87.66 re W n 0.961 w 1 j 1 J 262.5 611.7 22.86 -87.12 re S Q q 1 0 0 1 -8.535767 -1.877228 cm 1 g 319.2 524.58 22.62 102.24 re f Q q 1 0 0 1 -8.535767 -1.877228 cm 318.66 524.58 23.76 102.78 re W n 0.961 w 1 j 1 J 319.2 626.82 22.62 -102.24 re S Q q 1 0 0 1 -8.535767 -1.877228 cm 1 g 375.66 524.58 22.86 113.34 re f Q q 1 0 0 1 -8.535767 -1.877228 cm 375.12 524.58 24 113.88 re W n 0.961 w 1 j 1 J 375.66 637.92 22.86 -113.34 re S Q q 1 0 0 1 -8.535767 -1.877228 cm 0.06 w 1 j 1 J q 1 0 0 1 189 662.88 cm 0 0 m 0 -138.3 l -2.4 -138.3 m 2.4 -138.3 l -2.4 -110.64 m 2.4 -110.64 l -2.4 -82.98 m 2.4 -82.98 l -2.4 -55.32 m 2.4 -55.32 l -2.4 -27.66 m 2.4 -27.66 l -2.4 0 m 2.4 0 l 0 -138.3 m 226.56 -138.3 l 0 -140.7 m 0 -135.84 l 56.7 -140.7 m 56.7 -135.84 l 113.4 -140.7 m 113.4 -135.84 l 169.86 -140.7 m 169.86 -135.84 l 226.56 -140.7 m 226.56 -135.84 l S Q Q BT /TT1 1 Tf 7.9369 0 0 7.9369 170.1442 520.4828 Tm (0)Tj -0.0119 Tc -0.544 3.485 Td (20)Tj 0 3.485 TD (40)Tj T* (60)Tj T* (80)Tj -0.544 3.485 Td (100)Tj -0.0421 Tc 4.233 -18.884 Td [(P)-40.4 (l)-31.6 (ac)-63.7 (eb)-30.2 (o)]TJ -0.0107 Tc 0.363 -1.3 Td [(n=4)-6.4 (6)1.2 (3)]TJ -0.0027 Tc 6.63 1.3 Td [(VIAG)-18.6 (R)-6.3 (A)]TJ -0.0107 Tc 0.005 Tw 0.544 -1.3 Td (25 mg)Tj 0 Tw -0.03 -1.308 Td [(n=2)-6.4 (1)1.2 (4)]TJ -0.0027 Tc 6.6 2.608 Td [(VIAG)-18.6 (R)-6.3 (A)]TJ -0.0107 Tc 0.005 Tw 0.544 -1.3 Td (50 mg)Tj 0 Tw -0.03 -1.308 Td [(n=3)-6.4 (9)1.2 (1)]TJ -0.0027 Tc 6.63 2.608 Td [(VIAG)-11.1 (R)-13.8 (A)]TJ -0.0109 Tc 0.0052 Tw 0.272 -1.3 Td (100 mg)Tj -0.0107 Tc 0 Tw 0.242 -1.308 Td [(n=3)-6.4 (8)1.2 (0)]TJ -0.0421 Tc 0.0364 Tw -12.927 -1.724 Td [(T)-73.8 (r)-41.7 (eat)-36.4 (m)-25.5 (en)-30.2 (t)-36.4 ( g)-30.2 (r)-41.7 (ou)-30.2 (p)]TJ 0.0019 Tc 0 Tw 0 7.9369 -7.9369 0 155.5642 518.3828 Tm [(Percentage pati)4.8 (ents reporti)4.8 (ng i)4.8 (m)3.3 (proveme)]TJ ET q 1 0 0 1 -8.535767 -1.877228 cm 156.78 520.2 9.18 148.26 re W n 1 0 0 1 8.535767 1.877228 cm BT 0 Tc 0 7.9369 -7.9369 0 155.5642 664.4228 Tm (n)Tj ET Q q 1 0 0 1 -8.535767 -1.877228 cm 1 g 209.4 559.98 28.86 13.68 re f Q BT -0.0119 Tc 7.9369 0 0 7.9369 203.0242 563.5028 Tm [(24)-7.6 (%)]TJ ET q 1 0 0 1 -8.535767 -1.877228 cm 1 g 377.82 638.64 21.9 14.16 re f Q BT 7.9369 0 0 7.9369 371.4442 642.6428 Tm (82%)Tj ET q 1 0 0 1 -8.535767 -1.877228 cm 1 g 322.56 627.54 21.9 14.22 re f Q BT 7.9369 0 0 7.9369 316.1842 631.6028 Tm (74%)Tj ET q 1 0 0 1 -8.535767 -1.877228 cm 1 g 266.34 613.14 21.9 14.16 re f Q BT 7.9369 0 0 7.9369 259.9642 617.1428 Tm [(63)-7.6 (%)]TJ /TT0 1 Tf 0 Tc 12 0 0 12 470.2042 467.0228 Tm ( )Tj 0.0011 Tc 0.0022 Tw 9 0 0 9 63.4642 458.6228 Tm ( )Tj 9 0 Td (Overall treatment p<0.0001 )Tj 0 Tc 0 Tw 12 0 0 12 63.4642 445.1828 Tm ( )Tj 0.0008 Tc 0.0006 Tw 10.98 0 0 10.98 203.9242 432.2228 Tm (Figure 4. Percentage of Patients Reporting )Tj 0.0011 Tc 0.0003 Tw 2.568 -1.159 Td [(an Im)8.4 (provem)8.4 (e)2.3 (nt in Erections. )]TJ 0 Tc 0 sildenafil 200 mg Tw 12 0 0 12 59.8642 405.7628 Tm ( )Tj 0.0006 Tc -0.0006 Tw 0.3 -1.165 Td (The patients in studies had varying degrees of ED. One-third to one-half\ of the subjects in these )Tj 0.0009 Tc -0.0009 Tw 0 -1.165 TD [(studies reported successful intercourse at leas)-2.2 (t once during a 4-week, treatm)8.7 (ent-free run-in )]TJ 0.0007 Tc 0 Tw T* (period. )Tj 0 Tc -0.3 -1.165 Td ( )Tj 0.0007 Tc -0.0007 Tw 0.3 -1.165 Td [(In m)8.5 (any of)3.7 ( the studies, of)3.7 ( both f)3.7 (i)-1.5 (xed dose and titration designs, daily diaries were kept by )]TJ 0.0008 Tc -0.0008 Tw T* (patients. In these studies, involving about 1600 patie)Tj 0.0006 Tc -0.0006 Tw 21.065 0 Td (nts, analyses of patient diaries showed no )Tj 0.0003 Tc -0.0003 Tw -21.065 -1.165 Td [(effect of VIAGRA on rates of attem)8.1 (pted interc)]TJ 0.0008 Tc -0.0008 Tw 18.69 0 Td (ourse \(about 2 per week\), but there was clear )Tj 0.0009 Tc -0.0009 Tw -18.69 -1.165 Td [(treatm)8.7 (ent-related im)8.7 (provem)8.7 (ent in sexual function: per patient weekly success rates averaged 1.3 )]TJ 0 Tc 0 Tw T* [(on 50-100 m)7.8 (g of VIAGRA vs 0.4 on placebo; si)]TJ 0.001 Tc -0.001 Tw 19.27 0 Td [(m)8.8 (ilarly, group m)8.8 (ean success rates \(total )]TJ 0.0006 Tc -0.0006 Tw -19.27 -1.165 Td [(successes divided by total attem)8.4 (p)0.6 (ts\) were about 66% on VIAGRA vs about 20% on placebo.

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)Tj 0 Tc T* ( )Tj 0.0007 Tc -0.0007 Tw T* [(Across all trials, VIAGRA im)8.5 (proved the erections)1 ( of 43% of radical prostatectom)8.5 (y patients )]TJ T* [(com)8.4 (p)0.6 (ared to 15% on placebo. )]TJ 0 Tc 0 Tw T* ( )Tj 0.0007 Tc -0.0007 Tw T* [(Subgroup analyses of responses to a global im)8.5 (provem)8.5 (ent question in patients with psychogenic )]TJ T* (etiology in two fixed-dose studies \(total n=179\) )Tj 0.0008 Tc -0.0008 Tw 19.345 0 Td (and two titration studies \(total n=149\) showed )Tj 0.0005 Tc -0.0005 Tw -19.345 -1.165 Td [(84% of VIAGRA patients reported im)8.3 (provem)8.3 (e)-0.7 (nt in)]TJ 0.0006 Tc -0.0006 Tw 20.61 0 Td [( erections com)8.4 (p)0.6 (ared with 26% of placebo. )]TJ 0.0005 Tc -0.0005 Tw -20.61 -1.165 Td [(The changes from)8.3 ( baseline in scoring on the two end point questions \(frequency of succe\ ssful )]TJ 0.0009 Tc -0.0009 Tw T* [(penetration during sexual activity and m)8.7 (aintenance of erections after penetration\) were highly )]TJ 0.0005 Tc -0.0005 Tw 0 -1.18 TD (statistically significantly in favor of VIAGRA)Tj /TT1 1 Tf 0 Tc 0 Tw 18.435 0 Td (. )Tj /TT0 1 Tf 0.0005 Tc -0.0005 Tw ( Diary data in two of the studies \(n=178\) showed )Tj -18.435 -1.165 Td [(rates of successful intercourse per attem)8.3 (p)0.5 (t of 70% for VIAGRA and 29% for placebo. )]TJ 0 Tc 0 Tw 0 -1.165 TD ( )Tj 0.0005 Tc -0.0005 Tw T* [(A review of population subgroups dem)8.3 (onstrated)]TJ 0.0007 Tc -0.0007 Tw ( efficacy regardless of baseline severity, )Tj 0.0003 Tc -0.0003 Tw T* (etiology, race and age.

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VIAGRA was effective in )Tj 0.0006 Tc -0.0006 Tw 20.005 0 Td (a broad range of ED patients, including those )Tj -20.005 -1.165 Td (with a history of coronary artery sildenafil citrate tablets 150 mg disease, hype)Tj 0.0011 Tc -0.0011 Tw 18.58 0 Td (rtension, other cardiac disease, peripheral vascular )Tj 0.0008 Tc -0.0008 Tw -18.58 -1.165 Td [(disease, diabetes m)8.6 (ellitus, depression, coronary artery bypass graft \(CABG\), radical )]TJ T* [(prostatectom)8.6 (y, transurethral resection of the prostate \(TURP\) and spinal cord inju\ ry, and in )]TJ 0.001 Tc -0.001 Tw T* (patients taking antidepressants/antipsychotics and antihypertensives/diu\ retics. )Tj 0 Tc 0 Tw T* ( )Tj 0.0004 Tc -0.0004 Tw T* (Analysis of the safety database showed no appa)Tj 0.0006 Tc -0.0006 Tw (rent difference in the side effect profile in )Tj 0.0004 Tc -0.0004 Tw T* (patients taking VIAGRA with and without anti)Tj 0.0008 Tc -0.0008 Tw 18.795 0 Td [(hypertensive m)8.6 (edication. This analysis was )]TJ 0.0006 Tc -0.0006 Tw -18.795 -1.165 Td [(perform)8.4 (e)-0.6 (d retrospectively, and was not powered to )-1.2 (detect any pre-specified difference in adverse )]TJ 0.001 Tc 0 Tw T* (reactions. )Tj 0 Tc T* ( )Tj T* ( )Tj /TT1 1 Tf -0.0013 Tc 0.0013 Tw 0 -1.18 TD [( )-13095 (INDICATION AND USAGE )]TJ /TT0 1 Tf 0.0005 Tc -0.0005 Tw 0 -1.155 TD [(VIAGRA is indicated for the treatm)8.3 (e)-0.7 (nt of erectile dysfunction. )]TJ 0 Tc 0 Tw 0 -1.165 TD ( )Tj T* ( )Tj ET /Artifact <>BDC Q q 1 0 0 1 120.6970062 785.2004395 cm /GS1 gs /Fm0 Do Q EMC /Artifact <>BDC q 1 0 0 1 612 773.2004395 cm /GS1 gs /Fm1 Do Q EMC endstream endobj 382 0 obj <>>>/Resources 385 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 65.791 -7.9 Td (This ) Tj 22.92 0 Td (label ) Tj 26.055 0 Td (may ) Tj 22.71 0 Td (not ) Tj 18.12 0 Td (be ) Tj 14.692 0 Td (the ) Tj 18.023 0 Td (latest ) Tj 29.595 0 Td (approved ) Tj 48.974 0 Td (by ) Tj 14.17 0 Td (FDA.

Altitude sickness

) Tj -281.05 -12 Td (For ) Tj 18.96 0 Td (current ) Tj 38.765 0 Td (labeling ) Tj 41.055 0 Td (information, ) Tj 61.25 0 Td (please ) Tj 34.707 0 Td (visit ) Tj 22.299 0 Td ( Tj ET endstream endobj 383 0 obj <>>>/Resources 387 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 0 -7.9 Td ( ) Tj ET endstream endobj 387 0 obj <> endobj 388 0 obj <> endobj 386 0 obj <>stream /This label may not be the latest approved by FDA. For current labeling information, please visit endstream endobj 385 0 obj <> endobj 389 0 obj <> endobj 384 0 obj <>stream /This label may not be the latest approved by FDA. For current labeling information, please visit endstream endobj 381 0 obj <> endobj 376 0 obj <>stream q 1 0 0 1 -8.535767 -1.877228 cm 0 0 612 792 re W n 1 0 0 1 8.535767 1.877228 cm BT /GS0 gs /TT0 1 Tf 12 0 0 12 63.4642 47.6228 Tm ( )Tj 19.25 -0.005 Td (8)Tj 0.0009 Tc -0.0009 Tw -19.25 54.94 Td [(on placebo. In the titration studies \(n=644\) \(with m)8.7 (o)0.9 (st patients eventually receiving 100 m)8.7 (g)0.9 (\), )]TJ 0.0011 Tc -0.0011 Tw sildenafil film tablet 0 -1.165 TD [(results were sim)8.9 (ilar. )]TJ 0 Tc 0 Tw -0.3 -1.165 Td ( )Tj 0.3 -17.655 Td ( )Tj ET q 1 0 0 1 -8.535767 -1.877228 cm 1 g 205.8 524.58 22.86 33.24 re f Q q 1 0 0 1 -8.535767 -1.877228 cm 205.26 524.58 24 33.78 re W n 0.961 w 1 j 1 J 205.8 557.82 22.86 -33.24 re S Q q 1 0 0 1 -8.535767 -1.877228 cm 1 g 262.5 524.58 22.86 87.12 re f Q q 1 0 0 1 -8.535767 -1.877228 cm 261.96 524.58 24 87.66 re W n 0.961 w 1 j 1 J 262.5 611.7 22.86 -87.12 re S Q q 1 0 0 1 -8.535767 -1.877228 cm 1 g 319.2 524.58 22.62 102.24 re f Q q 1 0 0 1 -8.535767 -1.877228 cm 318.66 524.58 23.76 102.78 re W n 0.961 w 1 j 1 J 319.2 626.82 22.62 -102.24 re S Q q 1 0 0 1 -8.535767 -1.877228 cm 1 g 375.66 524.58 22.86 113.34 re f Q q 1 0 0 1 -8.535767 -1.877228 cm 375.12 524.58 24 113.88 re W n 0.961 w 1 j 1 J 375.66 637.92 22.86 -113.34 re S Q q 1 0 0 1 -8.535767 -1.877228 cm 0.06 w 1 j 1 J q 1 0 0 1 189 662.88 cm 0 0 m 0 -138.3 l -2.4 -138.3 m 2.4 -138.3 l -2.4 -110.64 m 2.4 -110.64 l -2.4 -82.98 m 2.4 -82.98 l -2.4 -55.32 m 2.4 -55.32 l -2.4 -27.66 m 2.4 -27.66 l -2.4 0 m 2.4 0 l 0 -138.3 m 226.56 -138.3 l 0 -140.7 m 0 -135.84 l 56.7 -140.7 m 56.7 -135.84 l 113.4 -140.7 m 113.4 -135.84 l 169.86 -140.7 m 169.86 -135.84 l 226.56 -140.7 m 226.56 -135.84 l S Q Q BT /TT1 1 Tf 7.9369 0 0 7.9369 170.1442 520.4828 Tm (0)Tj -0.0119 Tc -0.544 3.485 Td (20)Tj 0 3.485 TD (40)Tj T* (60)Tj T* (80)Tj -0.544 3.485 Td (100)Tj -0.0421 Tc 4.233 -18.884 Td [(P)-40.4 (l)-31.6 (ac)-63.7 (eb)-30.2 (o)]TJ -0.0107 Tc 0.363 -1.3 Td [(n=4)-6.4 (6)1.2 (3)]TJ -0.0027 Tc 6.63 1.3 Td [(VIAG)-18.6 (R)-6.3 (A)]TJ -0.0107 Tc 0.005 Tw 0.544 -1.3 Td (25 mg)Tj 0 Tw -0.03 -1.308 Td [(n=2)-6.4 (1)1.2 (4)]TJ -0.0027 Tc 6.6 2.608 Td [(VIAG)-18.6 (R)-6.3 (A)]TJ -0.0107 Tc 0.005 Tw 0.544 -1.3 Td (50 mg)Tj 0 Tw -0.03 -1.308 Td [(n=3)-6.4 (9)1.2 (1)]TJ -0.0027 Tc 6.63 2.608 Td [(VIAG)-11.1 (R)-13.8 (A)]TJ -0.0109 Tc 0.0052 Tw 0.272 -1.3 Td (100 mg)Tj -0.0107 Tc 0 Tw 0.242 -1.308 Td [(n=3)-6.4 (8)1.2 (0)]TJ -0.0421 Tc 0.0364 Tw -12.927 -1.724 Td [(T)-73.8 (r)-41.7 (eat)-36.4 (m)-25.5 (en)-30.2 (t)-36.4 ( g)-30.2 (r)-41.7 (ou)-30.2 (p)]TJ 0.0019 Tc 0 Tw 0 7.9369 -7.9369 0 155.5642 518.3828 Tm [(Percentage pati)4.8 (ents reporti)4.8 (ng i)4.8 (m)3.3 (proveme)]TJ ET q 1 0 0 1 -8.535767 -1.877228 cm 156.78 520.2 9.18 148.26 re W n 1 0 0 1 8.535767 1.877228 cm BT 0 Tc 0 7.9369 -7.9369 0 155.5642 664.4228 Tm (n)Tj ET Q q 1 0 0 1 -8.535767 -1.877228 cm 1 g 209.4 559.98 28.86 13.68 re f Q BT -0.0119 Tc 7.9369 0 0 7.9369 203.0242 563.5028 Tm [(24)-7.6 (%)]TJ ET q 1 0 0 1 -8.535767 -1.877228 cm 1 g 377.82 638.64 21.9 14.16 re f Q BT 7.9369 0 0 7.9369 371.4442 642.6428 Tm (82%)Tj ET q 1 0 0 1 -8.535767 -1.877228 cm 1 g 322.56 627.54 21.9 14.22 re f Q BT 7.9369 0 0 7.9369 316.1842 631.6028 Tm (74%)Tj ET q 1 0 0 1 -8.535767 -1.877228 cm 1 g 266.34 613.14 21.9 14.16 re f Q BT 7.9369 0 0 7.9369 259.9642 617.1428 Tm [(63)-7.6 (%)]TJ /TT0 1 Tf 0 Tc 12 0 0 12 470.2042 467.0228 Tm ( )Tj 0.0011 Tc 0.0022 Tw 9 0 0 9 63.4642 458.6228 Tm ( )Tj 9 0 Td (Overall treatment p<0.0001 )Tj 0 Tc 0 Tw 12 0 0 12 63.4642 445.1828 Tm ( )Tj 0.0008 Tc 0.0006 Tw 10.98 0 0 10.98 203.9242 432.2228 Tm (Figure 4. )]TJ 0 Tc 0 Tw T* ( )Tj 0.0005 Tc -0.0005 Tw T* [(During 3 to 6 m)8.3 (onths of double-blind treatm)8.3 (e)-0.7 (nt or)]TJ 0.0008 Tc -0.0008 Tw 20.12 0 Td [( longer-term)8.6 ( \(1 year\), open-label studies, few )]TJ -20.12 -1.165 Td [(patients withdrew from)8.6 ( active treatm)8.6 (ent for any )]TJ 0.0005 Tc -0.0005 Tw 19.37 0 Td (reason, including lack of effectiveness.

At the )Tj 0.0007 Tc -0.0007 Tw -19.37 -1.165 Td [(end of the long-term)8.5 ( study, 88% of patients re)2.2 (ported that VIAGRA im)8.4 (proved their erections.

)]TJ 0 Tc 0 Tw T* ( )Tj 0.0007 Tc -0.0007 Tw T* (Men with untreated ED had relatively low baseline scores for all aspects\ of sexual function )Tj T* [(m)8.4 (easured \(again using a 5-point scale\) in the IIEF.